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| Solution Information | help | |
| Enzyme: | Nuclear receptor coactivator 1 | |
| inhibitor: | BDBM39443 | |
| substrate: | n/a | |
| Solution Type: | Aqueous | |
| pH at Preparation: | n/a | |
| Temp. Prep.: | n/a | |
| Comments: | Assay Overview: The purpose of this assay is to determine dose response curves for compounds identified as active in a previous set of experiments entitled, "Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma)" (PubChem AID 631). Additionally, compounds selected for testing in this AID were not active or exhibited at least a 3-fold lower % Activation value (compared to AID 631) in a set of experiments entitled, "Primary biochemical high throughput screening assay to identify agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by PPARgamma" (PubChem AID 1032) and "Primary biochemical high throughput screening assay to identify agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by PPARgamma" (PubChem AID 731). This assay tests the ability of compounds to increase interactions between PPARg and its coactivator SRC-1, | |
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